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Second, use of 2-DG in animal models impacts all cell types, including immunocytes
Conversely, p53 inhibits ferroptosis through the upregulation of cyclin dependent kinase inhibitor 1 A/p21 (cyclin dependent kinase inhibitor 1 A) expression in cancer cells (95)
Notably, GGsTop treatment blocked GGT activity and slowed tumour growth without causing any overt toxicity to animals (Fig
They house multiple oxidases that generate hydrogen peroxide (H 2 O 2 ) as a byproduct, which is subsequently neutralized by catalase (Okumoto et al., 2020)
