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This explains why dual GLP-1/GIP receptor agonists such as cotadutide, by synergistically activating both pathways, can not only significantly lower blood glucose but also more effectively reduce body weight and improve hepatic steatosis and inflammation, making them promising therapies for the comorbidity of T2DM, obesity, and MAFLD (97)

Perez-Mora, N., Velasco, C

However, this random conjugation strategy leads to a heterogeneous distribution of drug-to-antibody ratios (DARs), typically ranging from 0 to 8, and the uncertainty of conjugation sites may affect antigen binding or pharmacokinetic stability

Research in stem cells has suggested an upregulation of markers associated with neuronal differentiation, which could point toward possible roles in epigenetic regulation