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4 The multiscale anticancer mechanisms of SFN: beyond Nrf2 and HDAC inhibition While the activation of Nrf2-mediated antioxidant response and inhibition of HDACs represent well-established mechanisms underlying SFNs anticancer properties, emerging evidence reveals a far more complex pharmacological profile

Indeed, intracellular GSH ( r = 0.78, P = 0.003) and GSH:GSSG ( r = 0.60, P = 0.038) positively correlated with the SLC7A11/15LO1 protein ratio, without relation to intracellular GSSG

Experimental investigations demonstrate the capability of the catalyst to convert GSH in GSSG

It includes Vitamin E and C, glutathione (GSH), various carotenoids and flavonoids