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How a metabolite like l-2HG would specifically dampen suppressive genes is not understood

Nrf2 Regulates Downstream Genes by Targeting Mir-29b in Severe Asthma and the Role of Grape Seed Proanthocyanidin Extract in a Murine Model of Steroid-Insensitive Asthma
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Similarly, obesity is considered to be a key risk factor for heart failure (HF), CHD, and premature mortality [80,81,82]