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Description
Co-transfection experiment using p53-dependent reporter gene with p53 and MT expression vectors revealed that, when transfected in excess of MT as compared to p53, MT exerts an inhibitory effect, by an average of 50%, consistent with a metal chelator effect of MT
The metabolomic analysis was performed by following the Chemical Isotope Labeling (CIL) LC-MS protocol described in our previous report (81)
Homogenates were centrifuged at 1600 g at 4 C for 5 min
doi: 10.1016/j.jbc.2022.102312
