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Copper proteins incorporate copper ions through highly specific and stable coordinationsuch as binding to histidine or cysteine residuesto enable enzymatic activity or support structural functions (Kodama et al., 2012)

The latter process, collectively termed phagosome maturation, involves a sequence of strictly coordinated membrane fusion and fission events between the phagosome and compartments of the endo/lysosomal network [79, 80] and ultimately culminates with the formation of the phagolysosome, a highly degradative organelle equipped with potent microbicidal properties [81, 82]
