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Several factors, including cytokines, proteases, growth factors, gut microbiota, and dietary components are known to regulate intestinal TJs opening ( Intestinal epithelial cells and mononuclear phagocytes sense bacteria or their products mainly through pattern recognition receptors such as TLRs (166)

Second, we and other groups found that NO reduces inflammation and infection of insulin infusion cannulas and holds promise in enhancing the lifetime of such subcutaneously implanted cannulas [58,59]

Uric acid (UA), an end product from purine, which is one of the most important non-enzymatic antioxidants in the human serum

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