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Phosphorylation was first discovered to be of major importance in vertebrate circadian clock regulation in the tau mutation in Syrian hamsters, where a lowered rate of CKI-dependent phosphorylation of Per2 occurred, resulting in shortened period of free running rhythms (Lowrey et al., 2000)
J R Soc Med 1988
doi: 10.1016/j.aoas.2020.02.002 59
GPX4 knockdown levels were confirmed using a GPX4 antibody
