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The recommended daily intake of B12 is between 2.4 and 2.8 mcg, but its low absorption rate is the reason for such high dosages in supplements (NIH, 2020)

The spatial constraints of brachytherapy thus define a narrow therapeutic window, restricting opportunities for dose escalation that might otherwise improve outcomes in radioresistant or bulky tumors

5,6 Glucose-6-phosphate dehydrogenase (G6PD) deficiency G6PD deficiency is one of the most common human enzymopathies, estimated to affect 400 million people worldwide