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If the muscle and skin in this area is tethered down to the bone with a tight ligament (this is often called the orbitomalar ligament or the orbital retaining ligament but technically its the sub-orbicularis muscle fascia) then filler wont give you a good smoothing effect

The most beneficial methods include: 1

HighDose Intravenous Vitamin C, a Promising MultiTargeting Agent in Cancer Therapy Source: BioMed Central / Journal of Experimental & Clinical Cancer Research Summary: This article reviews mechanistic evidence and early clinical trials of high-dose IV vitamin C in oncology, detailing how pharmacologic ascorbate may exert cytotoxic effects in tumor cells, while reviewing limitations and future directions