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Baseline and interval laboratory monitoring should include: fasting glucose and HbA1c (tirzepatide can cause hypoglycemia in non-diabetic subjects if caloric intake drops too low), lipase and amylase (pancreatitis risk with GLP-1 agonists), liver function tests (AST, ALT, bilirubin), and thyroid panel (TSH, free T3, free T4)

The primary benefits for those with a deficiency include: Restoring energy levels and reducing fatigue

Slowly reducing B12 levels will impact the energy production in the mitochondria and the methylation pathways, affecting myelin production before it can create macrocytic anaemia (if ever)