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Review of the amphibian immune response to chytridiomycosis, and future directions

In normal cells, hydrogen peroxide is promptly degraded by either glutathione peroxidase (GSHPX) or catalase, but in red cells of G6PD-deficient subjects, GSHPX activity is impaired because GSH is in short supply (Fig 4), and catalase may also be impaired because the intracellular NADPH concentration is low (Gaetani et al , 1994, 1996)