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A deficiency in either of these vitamins can cause a wide range of problems, including: extreme tiredness a lack of energy pins and needles (paraesthesia) a sore and red tongue mouth ulcers muscle weakness disturbed vision psychological problems, which may include depression and problems with memory, understanding and judgement Some of these problems can also happen if you have a deficiency in vitamin B12 or folate but do not have anaemia

Some people notice a subtle energy boost or mood lift within 2448 hours , while others may experience more gradual, cumulative results with an ongoing injection protocol

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Results Thirteen studies were included in the meta-analysis, with a total of 4275 patients