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Patients with Gilberts syndrome might be more susceptible to acetaminophen-induced hepatotoxicity due to increased availability of the free drug for the oxidation pathway of metabolism [25,96]

Other enzymes involved in homocysteine metabolism include methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS), especially in vitamin B12 or folate deficiency

Poh KK, Lee PSS, Djohan AH, Galupo MJ, Songco GG, Yeo TC, Tan HC, Richards AM, Ye L

Although many studies have reported changes in DNA methylation or histone states alongside depressive or addiction-related phenotypes, it is still unclear whether these changes exert causal influence or simply arise as consequences of the disease process