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This transfer caused the mice to exhibit schizophrenia-associated behaviors, such as decreased social interaction and hyperactivity (increased total distance traveled and higher average speed in the Open-field test)

[DOI] [PMC free article] [PubMed] [Google Scholar] Li L, Di X, Wu M

Beyond its vital role as a coenzyme in energy metabolism, the important role of NAD + has expanded to be a co-substrate for various enzymes including sirtuins, PARPs, CD157, CD73, CD38 and SARM1

According to previous research, high levels of itaconate have been linked to cancer development and poor prognosis in some tumor forms (Weiss et al