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The PCA analysis of these metabolites (Figure 6A) clearly separated serum samples from the CK and UPL groups into distinct clusters

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66,67 Farnesoid X receptor (FXR), Wnt, and bone morphogenetic protein have also been shown to contribute to LPC differentiation into hepatocytes

Partial oxygenation results in a Hb conformational change that produces a dramatic increase in the rate of autoxidation and the affinity of Hb for the RBC membrane (Cao et al., Extracellular hemoglobin as a source for oxidative stress Extracellular Hb, whether originating from hemolysis of RBCs or the infusion of cell-free Hb-based blood substitutes, can be a major source for oxidative stress