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Decrease dose if: Experiencing consistent side effects (headaches, fatigue, GI disturbance), achieving satisfactory results at current dose with no need for escalation, or cost considerations favor using minimum effective dose

Using a sensitive analytical technique called mass spectrometry, they tracked the peptide as it was broken down by enzymes naturally present in the blood, and identified all the fragments that were produced

doi:10.3109/10408369609081009