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Accordingly, emerging structural and imaging tools such as corneal confocal microscopy and intraepidermal nerve fibre density assessment through skin biopsy have gained increasing relevance for the objective evaluation of early neural involvement and may provide complementary support to clinical and questionnaire-based assessment

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Clinical significance of this inhibition is demonstrated by the fact that inhibition of CYP3A4 by metformin results in reduced mitochondrial respiration leading to reductions in cancer cell growth

Electrolyte solidification: The viscosity of conventional lithium battery electrolytes increases sharply below -20C, lithium ion migration is hindered, and internal resistance soars
