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Oral B12 supplementation may be appropriate in specific circumstances: Dietary deficiency in individuals with normal absorption capacity (typically 50-150 micrograms daily) Patient preference (after discussion of relative efficacy) Maintenance therapy in selected cases Higher oral doses (10002000 micrograms daily) may be used in some cases, as only a small percentage is absorbed through passive diffusion when intrinsic factor-mediated absorption is impaired

Design and application in delivery system of intranasal antidepressants

1419), stable in human gastric juice, accordingly investigated in trials for inflammatory bowel disease, wound treatment, with no toxicity reported, where LD1 could be not achieved, effective alone without carrier (5-7, 9)

Secondary Plasma Amino Acids The levels of secondary (non-proteinogenic) plasma amino acids are given in Table 9