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Functional instability involves neuromuscular deficits including impaired proprioception, delayed muscle reaction times, and poor motor control that persist even when mechanical structures appear intact

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471 Similarly, in a randomized controlled trial in 3,144 non-cardioembolic stroke or TIA patients, low-dose colchicine (0.5 mg daily) did not reduce risks of stroke, heart attack, or unstable angina episodes during median follow-up of 33.6 months