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Cleveland Clinic Journal of Medicine

Digestive upset: Some patients report nausea, diarrhea, or stomach upset following injections

treatment often starts with an aggressive loading dose of 1000 mcg injections several times a week before tapering to monthly or bimonthly shots once levels stabilize

This finding relates, for example, to a decline in metabolism or the immune function 5,38,39 , large-scale changes in the blood transcriptome 40,41 , and other impairments of biological functions as a result of the preferential appearance of deep sleep, which in turn can cause partial sleep deprivation such as declines in st1 + 2 and stREM