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Description
The ATP-binding cassette-containing (ABC) family of proteins includes active drug efflux transporters like P-glycoprotein (P-gp), multidrug resistance-associated proteins (MRPs), and breast cancer-resistant protein (BCRP), which can exert a significant impact on placental transfer [85,86]

The pooled conversion rate from PD-NC to PD-MCI over follow-up times ranging from one to 16 years was 28% (95% CI 2433%)

Since melatonin influences DNMTs expression [84], it seems plausible that this compound may be a potential candidate that influences active DNA demethylation as well
Bulletin of Experimental Biology and Medicine, 135 (6), 590592
