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In cholangiocarcinoma, combined BET degradation and mTOR inhibition synergistically reduce acetylation of PSAT1-associated H3K27, inducing PSAT1 downregulation and subsequent dysfunction of the serine-glycine-one-carbon (SGOC) pathway (114)
therefore, it may be useful in patients with preeclampsia in response to placental ischemia, but not in normal pregnancies
The dual functions of thiol-based peroxidases in H(2)O(2) scavenging and signaling
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