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In analogy, genetic ablation of HO-1 amplified the development of atherosclerotic lesions and promoted their progression, thus confirming the protective role of HO-1 against atherogenesis (181)

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Katuno, et al., Rat and Guinea Pig Pancreatic Acini Possess Both VIP1 and VIP2 Receptors, which Mediate Enzyme Secretion, American journal of physiology Gastrointestinal and liver physiology, Vol

Importantly, both NOX1- and NOX2-produced ROS are required for the activation and differentiation of monocytes into proinflammatory M1 and anti-inflammatory M2 macrophages 77