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It is commonly referenced in preclinical and laboratory research examining cellular metabolism and enzyme-associated biochemical pathways within controlled research systems

Cell Adhes Commun 7:513523 Kaplan RC, McGinn AP, Pollak MN et al (2007) Association of total insulin-like growth factor-I, insulin-like growth factor binding protein-1 (IGFBP-1), and IGFBP-3 levels with incident coronary events and ischemic stroke

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However, these drugs sometimes become less effective because overuse leads to developing resistance to these drugs