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doi: 10.2337/db20-0361

A prominent player in cytokine-mediated tight junction regulation is myosin light chain kinase (MLCK) 56,65,66 , which disrupts the interaction between the tight junction proteins and the actin-myosin cytoskeleton, subsequently damaging the tight junction scaffold, which is crucial for the maintenance of barrier integrity 66,67,68

The core objective is to reduce documentation drift, the gradual divergence of naming strings, identity fields, and baseline handling statements across different documents and teams over time.

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