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This effect was associated with increased expression of IGF-1 and VEGF in the primary ossification zone.103 Altogether, the bone anabolic actions of the GH can be, at least in part, mediated by paracrine IGF-1 signaling, which enhances osteoblast activity.104 In fact, the only administration of recombinant IGF-1 to healthy participants results in an increase in circulating levels of bone remodeling markers

Plus, stimuli from the nose dont go through a peripheral nerve intermediary as do all other stimuli they shoot straight into the brain

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Nicotine pretreatment attenuated the loss of dopaminergic cells in MPTP-induced mesencephalic neurons (Quik and Jeyarasasingam, 2000)