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TJs, the principal regulators of paracellular permeability (62), are a network of proteins located at the apex of the lateral membrane of epithelial cells, including claudins (63), tight junction-associated marvel proteins (TAMPs) such as occludin (64), junctional adhesion molecule-A (JAM-A) (65), and intracellular scaffold proteins, such as zonula occludens (ZO), and tricellulin (66)

Because it has a short half-life, daily administration is common in literature to keep the IRR activated periodically

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End-to-end tracking visibility, a signature requirement on delivery, and thermal protection scaled to season and route apply to every outbound parcel without separate request