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Meaningful cosmetic changes often appear between three and six months of daily use

(1970) Characteristics of response of renal vascular bed to contrast media
Evaluation of clinical activity and safety of Daflon 500 mg in type 2 diabetic female patients

reported that 28.5% of their patients had new bone formation, which they termed callus formation in their study, with a mean follow-up of 21 months [12]
