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Rabbi Moshe Ben Maimon, Better Known as Rambam (1138-1204): Physician, Philosopher, and Adjudicator

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Of these, 25-HC plays a key role in the regulation of different cellular process such as lipid metabolism, modulation of immune response and suppression of viral pathogenesis.71 It was recently reported that 25-HC is part of the primary immune response against HCV infection since it regulates IFN response.53 As shown in figure 3, during HCV infection, IFN I or III induce the production of 25-HC by dendritic cells and macrophages residents of the liver.72 IFN induces the expression of the cholesterol 25-hydroxylase (CH25H) enzyme, which catalyzes the oxidation of cholesterol to 25-HC by the addition of a hydroxyl group on the side chain.73 25-hydroxycholesterol as part of the innate immune response against HCV