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These studies, which involved both pre-treatment and during-treatment dosing regimens, suggest that pharmacological inhibition of GlyT1 has been proposed as a strategy to diminish the rewarding effects of drugs of abuse
Furthermore, the water-soluble caspase inhibitor Ac-DEVD-CHO did not protect against the liver injury [162]
Heparin hepatotoxicity involved direct toxicity, hepatocyte membrane modification and immune-mediated hypersensitivity reaction [114]
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