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Aggregation Aggregation is when individual peptide molecules stick together, forming larger structures ranging from small dimers (two molecules) to large, visible clumps

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These medications have been shown to reduce relapse to opioid use, overdose, and HIV and HCV transmission, as well as improve other health outcomes.47 Buprenorphine is a partial -opioid agonist used for the maintenance treatment of opioid use disorder.2 Buprenorphine has potential merits, including a lower overdose risk and low ceiling effect for respiratory depression, fewer pharmaceutical interactions, and less risk of QTc-prolongation when compared to methadone.8 Buprenorphine is available in three formulations: sublingual films and tabs and buprenorphine extended-release injection (Sublocade ).4,6,7,9 The extended-release injectable formulation was approved by FDA in November 2017