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The meta-analysis by the Cholesterol Treatment Investigators Collaborative Group of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) and Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA)showed a 21% increase in risk of hemorrhagic stroke for every 1 mmol/L reduction in LDL-C ( Other adverse effects of statins include headache, insomnia, depression, and gastrointestinal symptoms such as dyspepsia, diarrhea, abdominal pain, and nausea

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Because SPCD is caused by permanent mutations in the SLC22A5 gene, a true cure would require repairing or replacing this gene [3] [4]

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CRISPR screens in synthetic lethality and combinatorial therapies for cancer

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