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Certain medications Some medications can also cause darkening, especially those that raise your insulin levels

Kun-Rodrigues, C

4-HNE represents a highly reactive lipid peroxidation byproduct that induces cellular damage by interacting with proteins, DNA, and other cellular components through iron- and oxygen-mediated chain-breaking reactions ( The transient receptor potential channel TRPM4 has been shown to promote ox-LDL-induced dysfunction in HCAECs through ferroptosis mechanisms ( Additionally, reduced sterol regulatory element-binding protein 1 (SREBP-1) expressiona key transcription factor in lipid and cholesterol metabolismis associated with stable CAD development

Second and third groups received the same treatments of GSH, but Zn was supplemented as foliar spray at 0.5 and 1 g L 1 , respectively