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Here, we profile key ferroptotic defence strategies including iron regulation, phospholipid modulation and enzymes and metabolite systems: glutathione reductase (GR), Ferroptosis suppressor protein 1 (FSP1), NAD(P)H Quinone Dehydrogenase 1 (NQO1), Dihydrofolate reductase (DHFR), retinal reductases and retinal dehydrogenases (RDH) and thioredoxin reductases (TR)

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In this study, molecular modelling techniques were employed, including high-throughput virtual screening (HTVS), followed by filtration procedures such as Lipinskis rule of five and Vebers rules, and finally CDOCKER docking, to prioritize compounds from the commercial Maybridge database