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To investigate the therapeutic potential on CTCs, mito-CD147 scFv adenovirus was administered via the tail vein to lactate-treated MMTV-PyMT spontaneous tumorigenic and PDX1-bearing mice that express native CD147 (Figs

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403,404 The PHERGain study explored whether it is possible to treat patients with early HER2+ breast cancer with dual antibody therapy alone in both neoadjuvant and adjuvant settings, completely sparing chemotherapy
