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& Varani, G
After desaturation, lycopene cyclase first forms -carotene by converting one of the acyclic ends of the lycopene as a -ring, then subsequently converts the other to form -carotene
Additionally, changes in the microenvironment, such as redox state, altered pH, and the presence of reactive oxygen species (ROS) at the pathophysiological sites, can act as sensitive stimuli to trigger drug release in those areas
Byrne NJ, Rajasekaran NS, Abel ED, Bugger H
