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However, it is not immediately available to the systemic circulation

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[84] [85] The 5-reductase inhibitors are contraindicated in pregnant women because of their teratogenicity due to interference with fetal testosterone metabolism, and as a precaution, pregnant women should not handle crushed or broken tablets

Furthermore, a number of endometrial miRNA gain and loss-of-function studies have demonstrated the critical functions of miR-200a, miR-429, and miR-145 in controlling embryo implantation and development ( Table 3 ) [295,296,297]