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Overcoming chemotherapy resistance using pH-sensitive hollow MnO 2 nanoshells that target the hypoxic tumor microenvironment of metastasized oral squamous cell carcinoma

However, it should be noted that the experiments were carried out in cell culture, which does not take into account factors such as the absorption and transportation of polyphenols when they are administered to the whole organism

The simultaneous presence of multiple NOX isoforms at different cellular locations and the production of ROS from other sources as well as the existence of endogenous enzymatic and nonenzymatic antioxidants rapidly reacting with superoxide anion and H 2 O 2 make the univocal attribution of observed effects to selective NOX inhibition challenging

Bioavailability enhancement of polymyxin B with novel drug delivery: development and optimization using quality-by-design approach