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Studies in humans have shown that CoQ 10 is safe and well-tolerated even at high doses (12002400 mg/day) although its effect on reversing functional decline of mitochondria is unclear (Schulz and Beal, 10 supplementation reported the lack of improvement in motor functions in patients with neurodegenerative diseases, which led the authors to conclude that the use of CoQ 10 in these patients is unnecessary (Liu and Wang, 10 supplementation could delay functional decline, particularly with regard to Parkinson's disease (Beal, 10 treatment in 452 patients at early or mid-stage Parkinson's disease reported improvements in daily activities and other parameters (Liu et al., 10 in 609 patients with early-stage Huntington's disease did not slow the rate of patients' functional decline (McGarry et al., 10 supplementation can delay the progression of Huntington's disease, at least in its early stages