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Common scenarios that lead to vitamin overdose include: Taking high doses of vitamin supplements Taking multiple supplements that contain the same vitamin Consuming a diet high in fortified foods and supplements Accidental ingestion and mistaking supplements for candy by children Accidental vitamin overdose can occur when a person takes more than the recommended dosage of a vitamin supplement or takes multiple supplements that contain the same vitamin

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Studies show that mitophagy related proteins, including PINK1, Parkin, LC3-I and Beclin1, are downregulated in vascular endothelial cells under hyperglycemic conditions (Xi et al., 2021

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