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Ngian GS, Guymer EK, Littlejohn GO

Sphingolipid dysregulation constitutes another core feature of AD lipid abnormalities, with ceramide accumulation strongly correlating with neurodegeneration

The analgesic mechanisms of cannabinoids involve both direct suppression of excitatory and inhibitory neurotransmitter release via synaptic vesicle modulation, and indirect modulation of neuronal excitability through inhibition of voltagegated ion channels [344]

A specialized NMDA receptor function in layer 5 recurrent microcircuitry of the adult rat prefrontal cortex
