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Expression of differentially expressed proteins was assessed in ovarian tumors obtained from platinum-sensitive (n = 15) versus platinum-resistant patients (n = 10), as well as matching tumors from patients at initial diagnosis and following relapse (n = 4)

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Interestingly, the existence of similar tail-like responses from mechanistically distinct agentssuch as PAMs and channel blockersmay represent an example of functional degeneracy ( Given that EAR-20 enhances macroscopic currents and reduces receptor desensitization, we have studied whether these effects are related to changes in single-channel properties, such as open probability, mean open time, burst duration or mean amplitude since single-channel recordings provide the resolution necessary to dissect these parameters and gain mechanistic insight into how EAR-20 modulates receptor gating at the molecular level (Parsons et al., 1993)