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Reynolds and colleagues observed that patients with low serum folate levels undergoing treatment with various antidepressant drugs had poorer therapeutic outcomes (, , )

It exerts anti-inflammatory effects by inhibiting the gene expression of pro-inflammatory cytokines such as IL-1, IL-1, IL-6, and IL-12p35, downregulating the activity of inflammatory enzymes like iNOS and COX-2, and suppressing key factors in inflammation signaling pathways such as NF-B, FOXO3a, and SIRT1(Parvez et al., 2019)

Effects of radix scrophulariae on hyperthyroidism assessed by metabonomics and network pharmacology

theta to high-fat diet mice regulated gut flora composition, increased gutliver folate levels and hepatic polyunsaturated fatty acid ratio, thereby preventing hepatic steatohepatitis and liver injury