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Description
Some research suggests that chronic high-dose L-carnitine supplementation may increase TMAO levels via gut bacteria metabolism, and elevated TMAO has been associated with increased cardiovascular risk in observational studies
In 1985, the International Conference on Nutrition held in Chicago classified L-carnitine as an "essential nutrient under specific conditions." By that time, 22 countries and regions worldwide had permitted the addition of L-carnitine to infant formula to prevent carnitine deficiency
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Given its multifaceted role, TMAO has garnered interest as both a biomarker and a therapeutic target
