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The general principle described in clinical teaching is to establish a baseline, recheck IGF-1 after the early weeks of any protocol, keep it within an age-appropriate reference range rather than pushing it into supraphysiologic territory, and monitor fasting glucose in at-risk patients

Some individuals may experience mild side effects such as nausea, bloating, or skin rashes, while others might be more sensitive and encounter allergic reactions or changes in skin pigmentation

In a recent study, compression bandages were applied in combination with topical cannabis-based medications to the wound bed and surrounding tissues to treat nonresponsive lower limb ulcers in 14 patients with an average age of 75 years [50]

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