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In contrast, those with CT or TT genotypes experience reduced GSS activity, leading to decreased GSH production and a higher susceptibility to oxidative stress

However, neither molecular mechanisms responsible for the APE/Ref-1 gene expression induction upon oxidative injury nor functional data regarding the real in vivo role played by post-translational modifications in controlling APE/Ref-1 functional activities are clear.24 Understanding the possible relationships existing between APE/Ref-1 levels and oxidative-stress-based human liver pathologies is of enormous importance, not only for the comprehension of the role and mechanism that APE/Ref-1 may play in the initiation and development of these pathologies but also for developing diagnostic markers and therapeutic tools

-TTP was first reported in rat liver by Hosomi et al., 1998

S.GambillL.GaoD.YaguchiA.BlennerM
