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It is characterized by ROS-induced dissociation of the oxygen-sensitive kinase KEAP1, activating the NRF2 signaling pathway and caspase-8-dependent cell death [241, 242]

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The relevance of the colon to zinc nutrition

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Aging also expands the amounts of immunosuppressive M2 macrophages in many mouse tissues, e.g., bone marrow, spleen, lungs, and skeletal muscles [135, 136]

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