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Data Availability Statement All data generated or analyzed during this study are included in this published article, including supplementary files, and can be downloaded from (accessed on 24 August 2019)

1993;265:L501L506

A mitochondria-targeted covalent organic framework (COF) prodrug that is selectively activated by high intramitochondrial GSH levels was shown to trigger catalase collapse within the organelle, thereby amplifying local chemodynamic therapy (CDT) through enhanced ROS accumulation and mitochondrial dysfunction

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