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In addition, primary culture in 2D and organotypic slice both showed reduced transcriptional signatures of cellular stress across principle dimensions, including glycolysis, endoplasmic reticulum stress, oxidative stress and apoptosis 53,54,55 (Extended Data Fig

This observation supports the hypothesis that the BER pathway alone can remove a certain type of bulky DNA lesions and ICLs (Noll et al., 2006

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